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Answered: What are histone deacetylase inhibitors (HDACi)? Give example(s) | bartleby

Dr Vandana Puri on Instagram: "HDAC inhibitors (HDACi) are drugs that increase histone acetylation, leading to open chromatin and increased gene expression.HDAC enzymes normally remove acetyl groups → chromatin becomes tight → genes OFF HDAC inhibitors block this removal → chromatin becomes open → genes ON Common HDAC Inhibitors Vorinostat (SAHA) Romidepsin Panobinostat Belinostat Valproic Acid Vorinostat (SAHA) FDA-approved for cutaneous T-cell lymphoma. 2. Romidepsin Also used for T-cell lymph