Aug 24, 2006 · Spastic paraplegia 7 (SPG7) is characterized by insidiously progressive bilateral leg weakness and spasticity. Most affected individuals have decreased vibration sense and cerebellar …

Spastic paraplegia type 7 (also called SPG7) is one of more than 80 genetic disorders known as hereditary spastic paraplegias. These disorders primarily affect the brain and spinal cord (central …

Patients with the pure form of SPG7 only experience spasticity and muscle weakness. However, a patient with the complex form of SPG7 will develop spasticity, muscle weakness, and ataxia.

Dec 4, 2025 · Spastic paraplegia-7 with or without cerebellar ataxia (SPG7) is an autosomal recessive neurologic disorder with onset of symptoms in adulthood, usually between 20 and 40 years of age. …

Aug 31, 2023 · SPG7 is caused by mutations in the SPG7 gene, which encodes a protein called paraplegin. People with SPG7 may experience symptoms such as spasticity, weakness, ataxia (lack …

Feb 20, 2025 · SPG7 variants are associated with a spectrum of mitochondrial disorder phenotypes, including progressive external ophthalmoplegia, and myopathy. Genetic testing for SPG7 should be …

4 days ago · SPG7 is an autosomal recessive hereditary spastic paraplegia caused by mutations in the paraplegin gene, presenting most commonly as late-onset progressive spastic gait (median age 39 …

Jan 15, 2026 · Spastic paraplegia 7, autosomal recessive (SPG7) [MIM:607259]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness …

Spastic paraplegia type 7 (SPG7) is part of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by progressive muscle stiffness (spasticity) and the …

Spastic paraplegia 7 (SPG7) is characterized by insidiously progressive bilateral leg weakness and spasticity. Most affected individuals have decreased vibration sense and cerebellar signs.