The protein responsible for movement of cilia and flagella was first discovered and named dynein in 1963 (Karp, 2005). 20 years later, cytoplasmic dynein, which had been suspected to exist since the …

In this review, we begin by discussing the assembly, motility, and regulation of the dynein-1 transport machinery, which also serves as a primer for other dynein motors. We then focus on how dynein-2, …

The core of dynein is composed of a ring of six AAA+ domains, similar to the engines that power the unfolding of proteins in AAA+ proteases. One of these, the AAA1 domain colored dark blue here, is …

Dynein is a minus-end-directed microtubule motor crucial to diverse cellular processes. The unwieldy size of the molecule and the difficulty of expressing and purifying mutants have hampered …

Dec 18, 2023 · In this primer, we first highlight the structure, mechanism, and regulation of dynein-1, which is the best-characterized member of the dynein motor family, and then describe the unique …

Sep 25, 2013 · Dynein is currently at the frontier of cell motility research at the molecular level, as its mechanism of movement is much less well understood than that of kinesin and myosin.

Sep 25, 2013 · Dynein is one of the three families of cytoskeletal motor protein. Originally identified 50 years ago as an ATPase in Tetrahymena pyriformis cilia3, dynein was named by Gibbons and Rowe …

Feb 26, 2019 · Dynein, one of three cytoskeletal motor protein families, was first identified a half century ago and got its name after the ‘dyne’ (i.e. a unit of force).

Compare and contrast the roles of dynein and kinesin in cellular transport mechanisms. Dynein and kinesin are both motor proteins that operate on microtubules but have opposite functions. Dynein …

Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs.