Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Researchers have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The results illuminate one of the ...

In a landmark technical achievement, investigators in the Vanderbilt Center for Structural Biology have used nuclear magnetic resonance (NMR) methods to determine the structure of the largest membrane ...

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new ...

Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The ...

Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The ...

Approximately 25 percent of proteins localize to membranes, where they act as receptors and signaling molecules in biological processes, including respiration, neurotransmission, and molecular ...

Membrane proteins are some of the most valuable targets in drug discovery, accounting for over half of all therapeutic targets. However, their inherent structural diversity and the complexity of their ...

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for binding with the human angiotensin-converting enzyme 2 (ACE2) receptor to facilitate host cell ...

At just 75 amino acids long, the envelope (E) protein is the smallest of the four structural proteins that make up the SARS-CoV-2 viral particle and is essential for the virus to infect cells. Data ...