LTag, an oncoprotein encoded by polyomaviruses (reviewed in ref. 1), has diverse biological functions and also performs essential functions in replicating the viral DNA (reviewed in refs 2–4). During ...
Molecular biologists document the first step in one type of tumor: a virus homes in on a cell's most important defender, inhibiting its anti-cancer properties. If anything in cancer biology can be ...
Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...
A group of scientists led by USC researcher Dr. Xiaojiang Chen lend structural insight into tumor suppressor inactivation by a viral oncoprotein. Their crystal structure of the large T antigen/p53 ...
If anything in cancer biology can be likened to a cage match, this is it: the battle inside the cell walls between LTag, "The Most Amazing Molecule in the Universe," and p53, "The Guardian of the ...
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